Cell Line Development Market Size (By Product Type: Reagents & Media, Equipment, and Accessories & Consumables; By Source: Mammalian, and Non-Mammalian; By Type of Cell Line: Recombinant, Hybridomas, Continuous Cell Line, and Primary Cell Line; By Application: Bioproduction, Drug Discovery, Toxicity Testing, Tissue Engineering, and Research) – Global Industry Analysis, Market Size, Opportunities and Forecast 2021 – 2028

Report Coverage

Global Cell Line Development Market Trends

One of the key factors fueling the cell line development market growth is the increased prevalence of cancer in developing and under-developing economies. The increase in the adoption of regenerative medicines, rising cancer prevalence globally, and soaring R&D investments by biotechnology and pharmaceutical companies are driving the cell line development market growth. Furthermore, the consistent investigation into drug discovery practices is expected to drive market growth over the forecast period. The complexity of developing stable cell lines, as well as the increased contamination due to the intense purification methods, may, however, limit the market's growth rate. In addition, the absence of regulatory standards and specific technical specifications for obtaining authorization poses a threat to the market under consideration.

Market Segmentation

Market by Product Type

• Reagents & Media
• Equipment
• • Incubator
  • Centrifuge
  • Bioreactor
  • Storage equipment
  • Microscope
  • Electroporators
  • FACS
  • Others

• Accessories & Consumables

Based on the product type, the reagents and media segment occupied the maximum market share in 2020. Cell culture reagents are necessary for the success of biologically relevant cell models in bioproduction and biomedical research. Media, supplements,andsera,are essential to culture reagents that promote proliferation, cell survival, and biological function. Moreover, the quality of these reagents has a direct impact on biotherapeutic production and experimental results. Besides that, selecting an optimized media for primary cells is essential for successful tissue culture assays and applications.

Market by Source

• Mammalian
• Non-Mammalian 
• • Insects
  • Amphibians

Based on the source, the mammalian segment held the dominant market share in 2020. Mammalian cell culture is essential for the development of protein therapeutics and viral vaccines. The demand for high-productivity production cell lines has increased as the number of innovator biologic and biosimilars products have grown, as has the demand for the mammalian segment. Viral infection and genetic engineering can also be used to programme mammalian cells to make vaccines and therapeutic proteins. Moreover, most pharmaceutical and biotechnology companies' mammalian cell line advancement technologies are currently based on either methotrexate amplification innovation or the glutamine synthetase system.

Market by Type of Cell Line

• Recombinant
• Hybridomas
• Continuous Cell Line
• Primary Cell Line

Based on the cell line, the recombinant segment is expected to grow at the fastest CAGR during the forecast period. The rapid growth of therapeutic recombinant proteins can be attributed in large part to technological advancements in vector interpretation, cell line culture engineering, and clone screening. Recombinant proteins can be developed using a variety of expression systems, including insect, yeast, microbial, mammalian cells, and transgenic cell systems. The primary goal of recombinant protein development is to create a monoclonal cell line, which is steady and continuously expresses the specified recombinant protein in high quantity and desired quality via a productive and cost-effective production process. However, due to the similarity of their metabolic and protein processing pathways to those of human cells, mammalian cell lines are the most commonly used production systems for recombinant proteins.

Market by Application

• Drug Discovery
• Toxicity Testing
• Bioproduction
• Tissue Engineering
• Research

In terms of application, the drug discovery segment is expected to account for a significant share of the market in the coming years. Stable cell lines are widely used in a wide range of critical applications, including biologics manufacturing, drug screening, tissue engineering, and functional genomics research. Recent technological advancements by cell line development experts have aided in the testing of various drug candidates during the early development phase, saving money and time. However, the collaboration between cell line development and drug development organizations has aided the growth of the cell-line development market.

Cell Line Development Market Regional Overview

 North America

• U.S.
• Canada

Europe

• U.K.
• Germany
• France
• Spain
• Rest of Europe

Latin America

• Brazil
• Mexico
• Rest of Latin America

Asia-Pacific

• China
• Japan
• India
• Australia
• South Korea
• Rest of Asia-Pacific

Middle East & Africa

• South Africa
• GCC
• Rest of Middle East & Africa

North America is likely to dominate the global cell line development market due to its well-established advanced healthcare infrastructure and services along with increasing government initiatives. Additionally, the market in the region is expected to benefit from the implementation of innovative technologies. The United States continues to dominate the North American region with a majority stake, thanks to government support to accelerate research in the biopharmaceutical and biotechnology sectors, which has increased the demand for cell line development. Moreover, the presence of key market players, combined with the positive initiatives undertaken by the governments of this region, supports the development of cell line development activities.

Competitive Landscape

Leading players profiled in global cell line developmentindustryreport are Sigma-Aldrich Corp., Lonza group AG, Corning Inc., Eurofins, GE Healthcare, GenScript Biotech Corporation, Syngene International Limited, Novartis, Samsung Biologics, Horizon Discovery, Thermo Fisher Scientific Inc., and Wuxi AppTec.