Digital Polymerase Chain Reaction Market Size - Global Industry, Share, Analysis, Trends and Forecast 2022 – 2030

The Global Digital Polymerase Chain Reaction Market Size accounted for USD 271.6 Million in 2021 and is projected to achieve a market size of USD 1,379.6 Million by 2030 rising at a CAGR of 19.9% from 2022 to 2030. Because of its potential applications in cell biology, genetic engineering, and medical diagnostics, digital polymerase chain reaction (dPCR) technology has remained a "hot topic" over the last two decades. Several advanced techniques for sample dispersion, thermal cycling, and digital PCR output monitoring have been reported. Digital PCR (dPCR) is a technique for quantifying nucleic acids (DNA, RNA, cDNA). Digital polymerase chain reaction (dPCR) determines the number of DNA targets (copies) per reaction partition using appropriately validated assays and without the need for a standard curve. Reaction partitions can be fixed chambers in a microfluidic device, known as chamber digital PCR (cdPCR), or aqueous-based droplets floating in oil, known as droplet digital PCR (ddPCR).

Digital Polymerase Chain Reaction Market Report Statistics

• Global digital polymerase chain reaction market revenue is estimated to reach USD 1,379.6 Million by 2030 with a CAGR of 19.9% from 2022 to 2030
• North America digital polymerase chain reaction market share accounted for over 35% shares in 2021
• According to the Our World in Data 2020, out of the 120 million samples tested for COVID-19, 49% have been done using rapid antigen testing”
• Asia-Pacific digital polymerase chain reaction market growth will register fastest CAGR from 2022 to 2030
• Based on technology, droplet digital PCR gathered over 75% of the overall market share in 2021
• Growing health issues will fuel the global digital PCR market value

COVID-19 impact on digital polymerase chain reaction (PCR) market

According to a report published by Medrxiv.org, ARS-CoV-2 nucleic acid detection by RT-PCR is one of the criteria approved by the China FDA for COVID-19 diagnosis. However, both the Chinese and US CDCs reported inaccurate test results (for example, a high false negative rate and some false positive rate) when using the RT-PCR method. SARS-CoV-2 was detected using a digital PCR (dPCR) instrument DropX-2000 and assay kits in 108 clinical specimens from 36 patients, including pharyngeal swabs, stool, and blood from various days during hospitalization. The lower detection limit of the optimized dPCR is at least ten times lower than that of RT-PCR. The overall clinical detection accuracy of dPCR is 96.3%. When compared to RT-PCR, digital PCR has a lower limit of detection, sensitivity, and accuracy, allowing COVID-19 detection with fewer false negative and false positive results, particularly for tests with low viral load specimens. Furthermore, dPCR is effective at detecting both asymptomatic and suspected patients. By quantifying an internal reference gene from human RNA in the PCR reactions, digital PCR can rule out negative results caused by insufficient sample loading.

Global Digital Polymerase Chain Reaction Market Dynamics

Market Drivers

• Rising diagnostic rate of infectious diseases
• Increasing healthcare spending per capita
• Historic growth of manufactures
• Positive impact of COVID-19 on digital PCR industry

Market Restraints

• High cost of digital polymerase chain reaction
• Lack of knowledge about dPCR

Market Opportunities

• Introduction of droplet digital PCR
• Rising advancement in the field of quantitative gene expression

Digital Polymerase Chain Reaction Market Report Coverage

COVID-19 Impact on Digital Polymerase Chain Reaction (PCR) Market

According to a report published by Medrxiv.org, ARS-CoV-2 nucleic acid detection by RT-PCR is one of the criteria approved by China FDA for COVID-19 diagnosis. However, both the Chinese and US CDCs reported inaccurate test results (for example, a high false negative rate and some false positive rate) when using the RT-PCR method. SARS-CoV-2 was detected using a digital PCR (dPCR) instrument DropX-2000 and assay kits in 108 clinical specimens from 36 patients, including pharyngeal swabs, stool, and blood from various days during hospitalization. The lower detection limit of the optimized dPCR is at least ten times lower than that of RT-PCR. The overall clinical detection accuracy of dPCR is 96.3%. When compared to RT-PCR, digital PCR has a lower limit of detection, sensitivity, and accuracy, allowing COVID-19 detection with fewer false negative and false positive results, particularly for tests with low viral load specimens. Furthermore, dPCR is effective at detecting both asymptomatic and suspected patients. By quantifying an internal reference gene from human RNA in the PCR reactions, digital PCR can rule out negative results caused by insufficient sample loading.

Digital PCR Market Insights

Digital Polymerase Chain Reaction (dPCR) market has 100% gains in virology applications

Virology currently has the most mature applications of dPCR for infectious disease diagnostics. dPCR has also found use in the rapidly growing field of gene therapy, allowing for the absolute quantification of viral gene vectors prior to administration as well as the measurement of vector copy numbers in target tissues. The superior precision provided by dPCR has also proven useful in emerging areas of virology, such as measuring cell-associated HIV DNA, HIV 2-LTR circles (a measure of failed HIV integration into the nucleus), cell-associated HIV RNA, and spliced HIV RNA, as well as estimating the size of the replication-competent HIV reservoir. Furthermore, the best application of dPCR in clinical testing is for the detection of inherited chromosomally integrated (ici) human herpes virus (HHV)-6. Furthermore, dPCR has been instrumental in identifying heterogeneity in WHO international standards for BK and JC viruses.

Technological advancements in dPCR to grow immensely in the coming years

Multiple dPCR assays have been described in medical practice for the detection of specific bacterial pathogens. For example, dPCR tests for Chlamydia trachomatis ocular infection and methicillin-resistant Staphylococcus aureus (MRSA) carriage have been expressly validated for clinical use. On the other hand, significant effort has been put into developing bacterial dPCR assays for food safety monitoring. When compared to standard practice methods, the use of dPCR in this context offers significant advantages in bypassing inhibitors that are inherent in many of the crude samples used as the substrate for testing, as well as greater simplicity and throughput in some cases. It should be noted that dPCR is still a developing technology, and the systems that are currently available are first- or, at best, second-generation platforms.

Digital PCR Market Restraint

High Cost of Digital Polymerase Chain Reaction (dPCR) impedes The Growth of Global Market

Despite rising cases of infectious diseases such as cancer and genetic disorders, as well as the high prevalence of these conditions in developing countries, the use of dPCR in these areas is still relatively low. This is due to a lack of knowledge about dPCR and its advanced forms in developing countries. Furthermore, the high cost of these devices further limits market penetration

Digital Polymerase Chain Reaction dPCR Market Segmentation

The worldwide digital polymerase chain reaction market is split based on technology, product type, application, end-user, and geography.

Digital Polymerase Chain Reaction Market By Technology

• Droplet Digital PCR
• Chip Based Digital PCR
• Beaming Digital PCR

Based on technology, ddPCR has been a significant revenue contributor to the global digital polymerase chain reaction market in the past and is expected to maintain its dominance during the forecast period. This is because the ddPCR technique precisely measures the number of DNA molecules in each drop. Furthermore, massive sample partitioning is an important aspect of the droplet digital PCR technique, which raises the demand.

Digital Polymerase Chain Reaction Market By Product Type

• Digital PCR Systems
• Consumables & Reagents
• Software & Services

The software and services segment is expected to grow the fastest in the coming years. Because the software aids in the efficient management of digital PCR data it is one of the prominent factors that foster segmental growth. As a result, there is an increase in demand for these products, propelling market growth.

Digital Polymerase Chain Reaction Market By Application

• Research
• Clinical Diagnostics
• Forensic & Others

According to digital polymerase chain reaction industry analysis, Digital PCR is a useful and powerful research tool because it is sensitive and specific. It has applications in translational medicine, basic research, and applied biology, among others. Gene research, medicine, oncology, forensics, stem cell research, and environmental microbiology are just a few of the applications for research, which is why the segment accounts for a sizable market share.

Digital Polymerase Chain Reaction Market By End-User

• Pharmaceuticals & Biotechnology Industries
• Clinical Diagnostic Laboratories
• Universities & Other Organizations

According to our digital PCR market forecast, the pharmaceuticals and biotechnology segment accounted for the majority of the share in 2021 and is expected to maintain this trend from 2022 to 2030. Clinical diagnostic laboratories, on the other hand, are expected to grow significantly in the coming years as the number of clinical trials and clinical centers increases.

Digital PCR Market Regional Outlook

North America

• U.S.
• Canada

Europe

• U.K.
• Germany
• France
• Spain
• Rest of Europe

Latin America

• Mexico
• Brazil
• Rest of Latin America

Asia-Pacific

• India
• Japan
• China
• Australia
• South Korea
• Rest of Asia-Pacific

The Middle East & Africa (MEA)

• Gulf Cooperation Council (GCC)
• South Africa
• Rest of the Middle East & Africa

Digital Polymerase Chain Reaction Market Regional Analysis

North America dominates; Asia-Pacific records fastest growing CAGR for the digital polymerase chain reaction (dPCR) market

The market attractiveness index for digital PCRs is expected to rise in North America. The region is distinguished by technological advancements, increased R&D spending, and improved healthcare infrastructure.

Asia-Pacific, on the other hand, is expected to have the fastest growing CAGR in the dPCR market in the coming years. Rising patient awareness will drive the Asia-Pacific advanced digital polymerase chain reaction (dPCR) market in the coming years. This is one of the most important factors contributing to regional growth.

Digital Polymerase Chain Reaction dPCR Market Players

Some of the key digital polymerase chain reaction companies in the market are Avance Biosciences, Bio-Rad Laboratories, Inc., Fluidigm Corporation, JN Medsys, The Merck Group, QIAGEN, Stilla Technologies Inc., Sysmex Corporation, Combinati, Inc., Thermo Fisher Scientific, and among others.