Cryopreservation Equipment Market (By Type: Freezers, Incubators, Sample Preparation Systems; By Cryogen: Liquid Nitrogen, Oxygen, Liquid Helium, Argon; By Application: Cord Blood Stem Cells, Sperms, Semen, Testicular Tissues, Embryos & Oocytes, Others; By End User: Stem Cell Banks, Biotechnology & Pharmaceutical Organizations, Stem Cell Research Laboratories, Others) - Global Industry Analysis, Market Size, Opportunities and Forecast 2020 - 2027

The global cryopreservation equipment market is expected to grow at a CAGR of around 6.4% from 2020 to 2027 and expected to reach the market value of around US$ 18.2 Bn by 2027.

Cryopreservation involving cooling and subsequent storage of frozen cells is considered as a critical process in providing a continuous source of tissue and genetically stable living cells for procedures. The procedures involve bone marrow transplant, organ donation, and in-vitro fertilization (IVF). Cryopreservation plays a vital role by inhibiting all biochemical activity that involves an apoptotic chemical reaction that prevents cell damaging.  

Cryopreservation is a complex process with inclusion of many variables that need to monitor under strict regulations. Techniques such as freezing, cellular metabolism, maintaining, cell viability, and providing optimized environment require a large amount of energy. As it is a lengthy process with techniques incorporating such as slow rate freezing and long term storage of the valuable cells coupled with consumption of large amount of energy to accurately maintain low temperatures. Therefore, implementation of equipments that consumes minimal energy without emission of waste products and cost effectiveness results into friendly cryopreservation.  

Market Dynamics

Cryopreservation by slow freezing technique is the standard procedure in cell culture preservation. As it is a largely used technique the rise of cell based therapies, accurate procedures, and regulations associated with medical or manufacturing standards result in driving the demand for cryopreservation equipment market.

In addition, incoming cellular material that does not comply with the appropriate bio preservation controls experience significant loss or reduction in functionality. Moreover, temperature excursions results in cell disruptions. Such factors contribute demand for cryopreservation equipments for maintenance of bi-product.

Market Trends

Cell Manufacturing and Bio-Banking

Cell therapy is an emerging technique that gives rise to regenerative medicine. Several chimeric antigen receptor (CAR) T-cell therapies received approval from the USFDA for treatment of leukemia and at least 500 other studies using CAR T-cells for cancer treatment are under clinical trials. Therefore, technology for cryopreservation is critical to offer high-quality cells that can achieve desirable outcomes. Good materials coupled with procedures for cryo-storing cells play a vital role in bio banking. This technique helps in maintaining human bio specimens that involve tumor cells, umbilical cord blood, and tissue-derived stem cells, as well as excess engineered cells in cases when repeated doses are needed for efficacious therapies. Such techniques act as regulators for driving cryopreservation equipment market worldwide.

Freezing Accelerates Cryopreservation Trend 

Cryopreservation has become a trend in daily routine for scientific research and medical application. This ranges from assisted production and transplantation to cell based therapies and biomarker identification. Cryopreservation by slow freezing is the golden rule in cell culture preservation. Besides slow freezing, vitrification technique has gained immensely strong attention in the minds of the manufacturers. Vitrification depends on fast freezing of the material by putting it in high concentration of cryo protectant and in contact with liquid nitrogen. Such method allows the direct transition of water from liquid to solid state without crystal formation. This procedure allows the concentrated cryo protectant from ice formation and therefore there is no need for slow freezing technique.

Segmental Outlook

Cryopreservation equipment market is segmented based on type, cryogen, application, and end-user.

By type, the market is segmented into freezers, incubators, sample preparation systems, and accessories. By cryogen, the market is classified as liquid nitrogen, oxygen, liquid helium, and argon. Further, by application the market is segmented as cord blood stem cells, sperms, semen, and testicular tissues, embryos & oocytes, and others. Finally, by end-user, the market is segmented as stem cell banks, biotechnology & pharmaceutical organizations, stem cell research laboratories, and others.

Based on type, freezers segment is expected to account for the highest revenue for the cryopreservation equipment market. This is due to heavy investment in R&D activities and merging and acquisition by the key participants that supports the growth of the freezers segment for cryopreservation equipment market. In addition, new product launches by the key participant’s enhances the capability to stay on the forefront by supporting the freezers segment in the global market.

Thermo fischer Scientific’s product involves cold storage freezers and sample preparation solution. Such product range provides sample protection for a wide range of sample types and larger range of storage conditions from 4⁰C high performance laboratory refrigerators to -196^oC cryogenic freezers.

In cryogen segment, liquid nitrogen will record remarkable market share for cryopreservation equipment market in the coming years. This can be achieved due to leading innovations in liquid nitrogen laboratory freezers. Liquid nitrogen is used as a preliminary choice in the cryopreservation equipment market. This can be attributed for companies manufacturing cryogenic freezers used liquid nitrogen as the refrigeration medium. As liquid nitrogen vaporizes, the cold vapors are circulated towards the in-feed end where it is used as pre-cooling and responsible for initial freezing of the product. Moreover, low temperature of the liquid nitrogen provides rapid freezing that enrich to reduce dehydration of products and improve quality.

Regional Overview

North America is anticipated to gain significant market share for cryopreservation equipment market followed by Asia Pacific. This is attributed to ongoing R&D activities across the region that serves as a prominent growth factor for regional growth of cryopreservation equipment market. 

In February 2016, Renueron a UK based stem cell research company received a US patent for a cryopreservation technology that is not supported by toxic reagent and is considered for other licensing to other stem cell therapy developers. Such new processing technology supports automated production in the US to further streamline the manufacturing process. Such factors contribute utmost for the growth of cryopreservation equipment market in North America.

On the other hand, Asia Pacific will also witness significant growth in the forthcoming years owing to ongoing R&D activities in stem cell research.

In December 2020, a number of projects have been supported for stem cells research in India. The Department of Biotechnology (DBT) in India has implemented several programs for the research in stem cell that is identified as a lucrative program. One such program is Indo-Japan collaborative program that study the major brain and blood disorders in Indian population through combination of clinical investigations, modern human genetics, and stem cell technology. This program has a strong component in iPsc research.

Competitive Landscape

Key companies profiled in this report involve Thermo Fisher Scientific Inc., Cryogenic Control, Linde LLC, Haimen United Laboratory Equipment Development Co., Ltd., Merck KGaA, Asymptote Limited, and Custom Biogenic System, and among others.

Market Segmentation

Market By Type

Freezers

Incubators

Sample Preparation Systems

Market By Cryogen

Liquid Nitrogen

Oxygen

Liquid Helium

Argon

Market By Application

Cord Blood Stem Cells

Sperms

Semen

Testicular Tissues

Embryos & Oocytes

Others

Market By End User

Stem Cell Banks

Biotechnology & Pharmaceutical Organizations

Stem Cell Research Laboratories

Others

Market By Geography

North America

• U.S.
• Canada

Europe

• U.K.
• Germany
• France
• Spain
• Rest of Europe

Asia-Pacific

• China
• Japan
• India
• Australia
• South Korea
• Rest of Asia-Pacific

Latin America

• Brazil
• Mexico
• Rest of Latin America

Middle East & Africa

• GCC
• South Africa
• Rest of Middle East & Africa